Check out the iPad option for a paperless classroom here.
Hand out/Hand in features
Once the file is selected and sent to students, they will have to check their "handouts" folder, click the file and it should open in the app association you have created for the file type of the "handout."
I have created a generic student Dropbox account. Within this account, I have created a folder for this years class. Within this folder is an individual folder for each student. I have also shared this folder with my own personal Dropbox account. I can put files into this shared folder and they will automatically be accessible by my students.
They will start by clicking the "to do" folder to access the files for the day. They will then click on the file and choose which application to open the file for annotation (we will use Note Anytime).
One of the big reasons I am using this method is the ability to share the annotated files. By saving into Dropbox, students or I can click on the files and share. When shared, you are provided a link. This link can be posted onto their Kidblog accounts, sent to parents or added to Evernote. All of these can serve as portfolios as we create digital artifacts.